Atherosclerosis Clinical Trial
Official title:
Search a Correlation Between Lipoprotein(a) Rate and TFPI(Tissue Factor Pathway Inhibitor)Activity in Obese Patients With Chest Pain Like Angina
Atherosclerotic cardiovascular disease is a leading cause of mortality in our countries.
Clinically, symptoms could be chest pain suggesting stable angina. Atherosclerosis is
influenced by cardiovascular risk factors which obesity (Body Mass Index>30). Obesity is
associated with an increase risk of cardiovascular complications.
Lipoprotein(a) is regarded as an independent risk factor for premature cardiovascular
disease. Lp(a) is composed of low-density lipoprotein - like particle bound to glycoprotein
molecule: apolipoprotein(a). Plasma levels are determinated to more than 90% by genetic
factors (no significant influence of statin, weight, lifestyle factor: diet, exercise). Two
study with few patients have found that aspirin lowers serum Lp(a) levels. Elevated Lp(a) is
a risk factor for recurrent coronary events in obese patient.
Atherosclerosis is associated with imbalance of coagulation. TFPI (tissue factor pathway
inhibitor) is the earliest inhibitor of the blood coagulation process, natural direct
inhibitor of tissue factor. In-vitro, TFPI activity is inhibited by high Lp(a) .
The aim of this study is to research reverse association between Lp(a) and TFPI activity in
obese patient with chest pain like stable angina suggesting atherosclerotic heart disease
and effect of aspirin.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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