A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

Atherosclerosis Clinical Trial

— IMT  

Official title:

A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00784264
• Other study ID #: NIS-CHK-DUM-2008/1
• Status: Completed
• Phase: N/A
• First received: October 22, 2008
• Last updated: January 11, 2010
• Start date: October 2008
• Est. completion date: June 2009

Study information

• Verified date: January 2010
• Source: AstraZeneca
• Contact: n/a
• Is FDA regulated: No
• Health authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee
• Study type: Observational

Clinical Trial Summary

This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 200
• Est. completion date: June 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 45 Years and older

Eligibility

Inclusion Criteria:

• Male or female aged 55 years or above.

• Waist circumference: male more than 90 cm; female more than 80 cm.

Exclusion Criteria:

• Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia.

• Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease.

• Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Atherosclerosis

Locations

Country	Name	City	State
Hong Kong	Research Site	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
AstraZeneca

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong,		during the one single study visit	No
Secondary	To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong.		During the one single study visit	No
Secondary	IMT results to be compared with what being reported in the recent literature on normal Chinese population.		During the one single study visit	No