Atherosclerosis Clinical Trial
Official title:
Premature Atherosclerosis in Systemic Lupus Erythematosus: a Prospective Cohort Study
Patients with SLE have increased rates of atherosclerosis, while the risk factors for atherosclerosis in those patients were not fully revealed. This study is an observational study to investigate the natural process and risk factors for atherosclerosis based on a Chinese SLE cohort. Carotid intima media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) will be measured for each patient at baseline and 5-year follow-up. Blood tests including cholesterol levels, fasting plasma glucose levels and etc. will also be performed.
Accelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE),
and it leads to increased cardiovascular morbidity and mortality in patients with SLE.
Prevention and intervention of premature atherosclerosis is beneficial for prognosis and
survival of patients with SLE.
The primary aim of this study was to investigate the natural progress of carotid intima media
thickness (CIMT) in 5 years, and examine the risk factors for progression of CIMT and
atherosclerotic plaques based on a Chinese SLE cohort. The secondary aims of the study were
to investigate progression of brachial-ankle pulse wave velocity (baPWV), and to examine the
risk factors for increasing baPWV in patients with SLE.
Based on sample size calculation, 440 patients who meet the eligibility criteria will be
enrolled in this study. All patients will be enrolled from Peking Union Medical College
Hospital. After informed consent is obtained, the patients will be comprehensively evaluated
from demographic characteristics, medical history, clinical assessments, laboratory tests
results, CIMT and baPWV at baseline and 5-year follow-up. Descriptive analysis, univariate
analysis, and multivariate analysis will be used to analyze the correlation between potential
risk factors and CIMT/baPWV.
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