A Retrospective Study on the Differentiation Between Cough Variant Asthma and Chronic Cough

Asthma Clinical Trial

Official title:

A Retrospective Study on the Differentiation Between Cough Variant Asthma and Chronic Cough

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06199830
• Other study ID #: 2023-KLS-100-01
• Status: Completed
• Start date: March 1, 2022
• Est. completion date: August 31, 2023

Study information

• Verified date: December 2023
• Source: The First Affiliated Hospital of Zhejiang Chinese Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.

Description:

the investigators retrospectively collected information from patients with chronic cough who underwent pulmonary tests at the First Affiliated Hospital of Zhejiang Chinese Medical University from January 2019 to December 2019. Data of external test were also from the First Affiliated Hospital of Zhejiang Chinese Medical University, and time period was from January 2023 to April 2023.Pulmonary function test and methacholine challenge test was performed by professional technicians. Characters between patients with cough variant asthma and chronic cough were compared to establish a diagnostic model.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 645
• Est. completion date: August 31, 2023
• Est. primary completion date: May 20, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• (1) age from 18 years old to 65 years old; (2) clinical diagnosis of CVA and CC .

Exclusion Criteria:

• Exclusion criteria for CVA were: a history of COPD, bronchiectasis, bronchitis, cystic fibrosisor pneumonia, interstitial lung disease, pulmonary tuberculosis, lung cancer; cough caused by drugs or treatments; patients with upper airway cough syndromes (UACS) and gastroesophageal reflux-related cough (GERC) or other apparent causes of cough; patients who used corticosteroid (ICS) in the previous four weeks; Exclusion criteria for CC were: a history of variable airway limitation.

Related Conditions & MeSH terms

• Asthma
• Chronic Cough
• Cough

Intervention

Diagnostic Test:
• positive bronchial provocation test
Patients were asked to inhale gradually increasing doses of methacholine (0.9% saline, 0.078, 0.312, 1.125 and 2.504 mg), and FEV1 was measured after each inhalation. This test was stopped until a reducing in baseline FEV1 of 20%.

Locations

Country	Name	City	State
China	The First Affiliated Hospital of Zhejiang Chinese Medical University	Hangzhou

Sponsors (1)

Lead Sponsor	Collaborator
The First Affiliated Hospital of Zhejiang Chinese Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	positive bronchial provocation test	Patients were asked to inhale gradually increasing doses of methacholine (0.9% saline, 0.078, 0.312, 1.125 and 2.504 mg), and FEV1 was measured after each inhalation. This test was stopped until a reducing in baseline FEV1 of 20%	up to 1 week
Secondary	small airway dysfuction	MMEF% pred, FEF50% pred, FEF75% pred	up to 1 week