Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05165953 |
| Other study ID # |
TEJB-D-21-00113 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
December 1, 2020 |
| Est. completion date |
October 15, 2021 |
Study information
| Verified date |
December 2021 |
| Source |
Benha University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Background: Asthma is still considered a major chronic respiratory disease that affects a
large number in the world. The association between COVID-19 infection and asthma was studied
in different ways focusing on hospital admitted patients. This study aimed to evaluate the
relation between asthma and COVID-19 infection in adults attending outpatient pulmonary
clinic over three successive months from clinical and laboratory point of view. Patients and
methods: The current study collected 1309 patients attending the outpatient pulmonary clinic
of a Saudi Arabian private Hospital over three successive months from 1st of December 2020 to
the end of February 2021. Patients were divided into three groups; Group 1: COVID-19 infected
with asthma (312), Group 2: COVID-19 infected with no asthma (286) and Group 3: COVID-19
non-infected with asthma (300).
Description:
The current study aimed to evaluate the relation between asthma and COVID-19 infection in
adults attending outpatient pulmonary clinic over three successive months from clinical and
laboratory point of view.
Patients and methods:
The current study is a retrospective analytical study on 1309 patients attending pulmonary
clinic in a Saudi Arabian private hospital over three successive month's starting from the
1st of December 2020 to the end of February 2021. Patients were classified according to
previous history of asthma and /or infection with covid -19 in the previous 6 months.
Patients were divided into two main groups according to history of COVID-19 infection;
history of COVID-19 infection , no history of COVID-19 infection. Each group was divided into
asthma and non-asthma groups. Patients who had no history of asthma and had no history of
previous infection with COVID-19 were excluded from the study. So, the investigators get
three groups: Group 1: COVID-19 positive with asthma, Group 2: COVID-19 positive with no
asthma and Group 3: COVID-19 negative with asthma. The study was approved by local internal
ethics committee and patient's acceptance to reveal their data was received prior to the
study.
Methods: data were collected from medical records including: history of COVID -19 infection,
presenting symptoms and clinical examination, hospitalization either ICU or ward. For asthma
patients, their full data were collected regarding asthma control in last 3 months following
GINA criteria for asthma control [8], Investigations included; CBC with differential count,
WBC, lymphocytes, eosinophils, HGB and platelets, Inflammatory markers as d-dimer, LDH and
ferritin level, electrolytes, BUN, serum creatinine, CXR, and old spirometry reports.
Diagnosis of COVID 19 infection was made by a positive nasopharyngeal and throat swabs COVID
19 polymerase chain reaction (PCR). The data were collected from patients' medical records
including medical history, demographic information such as age, gender, symptoms of COVID-19,
time of onset of symptoms, the physical examination at admission, during hospitalization,
medications prescribed for COIVID-19 treatment, laboratory examinations, and imaging tests
which were performed for all groups.
The data were analyzed using SPSS 22 (SPSS Inc., Chicago, IL, USA). The results were
presented as percentile (absolute numbers); mean and standard deviation. Quantitative data
were presented as median (interquartile range) (IQR, presented as first quartile - third
quartile). Qualitative data were expressed as percentage (%) [9].
