Asthma Clinical Trial
Official title:
Towards Targeting the ORigin of the Inflammatory Cascade in Allergic Asthma: Cross-talk Between Airway Epithelium and Immune Cells
Allergic asthma is a complex and heterogeneous disease caused by excessive responses to
inhaled allergens. Current medication, including corticosteroids and bronchodilators, does
not act on the origin of inflammation but rather combats symptoms, leaving many patients
uncontrolled. Airway epithelium is critical for the initiation and progression of asthma
pathology.
We will include a 52 subjects divided over two groups: ongoing asthma (26 patients) and
non-asthmatic healthy controls (26 subjects) in a cross-sectional study. All subjects will be
extensively clinically characterized including respiratory symptoms/questionnaires, in- and
expiratory CT-scans, and parameters of large and small airway function and inflammation. In
addition, blood and nasal epithelial brushes will be obtained to study the genetic and
epigenetic mechanisms of asthma. Finally, bronchoscopy with bronchial biopsies and brushes
will be performed under conscious sedation. Bronchial biopsies from both patient groups will
be used for single cell transcriptional analysis.
n/a
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