MRI and Lung Function Measures of Benralizumab Response in Asthma

Asthma Clinical Trial

— MR BEN  

Official title:

Using Benralizumab to Explore Treatment Response Patterns in Functional Lung MRI and Advanced Measures of Lung Function

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT04182802
• Other study ID #: STH20679
• Status: Withdrawn
• Start date: February 13, 2020
• Est. completion date: July 1, 2022

Study information

• Verified date: November 2019
• Source: Sheffield Teaching Hospitals NHS Foundation Trust
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

New treatments have been developed for asthma that are good at preventing asthma attacks and improving day-to-day symptoms. Alongside the development of these new drugs, there are new ways of measuring how the lung is affected by asthma. In particular, investigators have developed ways of seeing how air moves in the lungs of people with asthma, using MRI scanning. This study aims to see how quickly these new drugs result in changes in the way the lung is working, as seen in the MRI scans and other breathing tests. This will help clinicians in the future to decide who is likely to respond to these new medicines, and once patients have started taking the drugs, will help clinicians to decide whether long term treatment is likely to benefit the people receiving them.

In this study, the investigators plan to do extra breathing tests and MRI scans on people who are receiving the drug as part of their usual clinical care. The study will not change an individual's treatment, but will give the investigators more information about the patients' illnesses and the way the patients' bodies respond to treatment.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: July 1, 2022
• Est. primary completion date: January 1, 2022
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• People with eosinophilic asthma meeting the National Institute for Health and Clinical Excellence (NICE) criteria for benralizumab therapy based on eosinophil count and exacerbation rates will be offered the chance to participate in this study.

Exclusion Criteria:

• Any medical illness that in the opinion of the investigator is likely to significantly impact on the response to benralizumab or the outcome of the MRI and lung function testing.

• Non-concordance with routine asthma therapies (this would be assessed as a mandatory part of NICE-based criteria).

• Any additional significant lung illness that would impact on likelihood of response to benralizumab. Of note, trivial stable bronchiectasis that in the opinion of the patient's clinician is not clinically significant nor likely to result in either recurrent exacerbations or impairment of interpretation of investigation results will not be exclusion criteria. Part of the initial inclusion regarding eligibility by NICE criteria include an assessment of a likely eosinophilic asthmatic phenotype with probability of treatment response, and potential subjects with complex lung disease would be unlikely to be eligible.

• Current cigarette smoking, or cigarette smoking within the past 6 months

• Significant lifetime smoking history of =20 pack years

• Previous use of another biologic therapy targeting eosinophils within 6 months of enrollment

• Pregnancy, planning pregnancy, or breast feeding. Women of childbearing potential must use effective contraception (concordant use of hormonal contraceptive, intrauterine device, total abstinence), and urine pregnancy tests will be performed before scans.

• Abnormal renal function (eGFR <30), to avoid risks from Gadolinium chelate MRI contrast agents.

Related Conditions & MeSH terms

• Asthma

Locations

Country	Name	City	State
n/a

Sponsors (4)

Lead Sponsor	Collaborator
Sheffield Teaching Hospitals NHS Foundation Trust	AstraZeneca, University of Dundee, University of Sheffield

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in percentage ventilated lung volume	Measurement of lung volume assessed by magnetic resonance imaging	Baseline to 16 weeks