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Clinical Trial Summary

Sputum induction is considered a relatively non-invasive, reliable procedure, which can be utilised to characterise the inflammatory profile of the airways.

However, the procedure can be slightly uncomfortable for patients. This study aims to assess the differences in participants' tolerability of sputum induction, by comparing two different nebulisers when performing the procedure.


Clinical Trial Description

This is a single centre, crossover study to compare the use of two nebulisers in the sputum induction procedure. 54 participants with stable asthma or COPD will be recruited and will attend 2 visits, at least 48 hours apart. Differences in the quality and quantity of samples and the time taken to produce a sample will be described. The main purpose is to explore the optimum device to perform the procedure, whilst protecting the safety of participants and maximising their comfort.

If participants are unable to produce a sputum sample after completion of the induction procedure, physiotherapy techniques may be performed. This is an exploratory objective to establish whether these techniques may help in the event of unsuccessful procedures. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04182009
Study type Interventional
Source University of Nottingham
Contact Dr Paula Almeida, PT, DHSc
Phone 0115 9691169
Email paula.almeida@nottingham.ac.uk
Status Recruiting
Phase N/A
Start date September 17, 2018
Completion date December 31, 2019

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