Asthma Clinical Trial
Official title:
The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome: A Comparison of Asthma Outcomes in Smoking vs Non-smoking Patients With an Incomplete Reversibility of Airway Obstruction (IRAO)
RATIONALE:
In asthmatic subjects, smoking can lead to several changes in disease characterictics. in
smokers of more than 20 pack-years, chronic obstructive pulmonary disease (COPD) can be
associated with asthma, also called asthma-COPD overlap syndrome (ACOS). Increasing data
support the concept that ACOS is a clinical entity. However, this should be further studied
in order to better target therapy.
AIM:
The objective of this study is to evaluate the comparative features of ACOS
METHODS:
This will be a descriptive study comparing the features of the ACOS with the features of
asthmatic subjects with an incomplete reversibility of airway obstruction (IRAO).The study
will be done over 1 or 2 visits (within a week interval), according to subjects'
availability. The visit will include completion of different questionnaires (asthma control
asthma quality of life, medical history, exacerbations, etc.), a thoracic examination,
allergy skin-prick tests, spirometry and bronchodilator response, lung volumes and compliance
measurements, exhaled nitric oxide measurement, blood sampling and a sputum induction.
n/a
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