Asthma Clinical Trial
Official title:
The Effect of Deep Inhalation on Mannitol Responsiveness
The study will assess how the inhalation technique used (deep inhalations versus tidal breathing) influences the results of a mannitol challenge test and a methacholine challenge test, if at all.
This study will look at airway responsiveness to inhaled methacholine and mannitol
administered with and without deep inhalation. This study will also investigate the role of
airway inflammation on these responses, using sputum differential cell counts and fractional
exhaled nitric oxide.
This is a single center, open label, randomized study. Individuals with stable asthma will be
eligible for enrollment. The study will consist of two parts, screening and testing.
Part 1: Screening
Participants will undergo consent procedures and assessments of fractional exhaled nitric
oxide levels, airway responsiveness to methacholine and sputum induction. If participants
show airway responsiveness to methacholine (i.e. methacholine PC20 16mg/mL), they will be
scheduled to undergo the testing part of the study.
Part 2: Testing
Participants will be randomized to undergo two methacholine or two mannitol challenges.
Further randomization will occur with respect to whether the standard challenge method or the
modified challenge method is performed first.
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