Asthma Clinical Trial
Official title:
Circulating Innate Lymphoid Cell Type 2 (ILC2) Levels and Asthma: a Case-control Study
The primary objective of this study is to demonstrate differences in ILC2 blood levels between asthma patients and control patients.
The secondary objectives of this study are:
To show that ILC2 levels differ between asthma patients with a "TH2" (helper T cell type 2)
profile and asthma patients with a "non-TH2" profile. A TH2 profile is defined as (for a
given patient):
- circulating eosinophils > 500 mm^3 at least once during the year AND
- positive allergy skin or specific IgE (Immunoglobulin E) test AND
- induced sputum eosinophil level >3% of leukocytes AND
- exhaled nitric oxide > 25 ppb.
To study the variation in ILC2 levels over time among asthma patients who obtained a good
level of control compared to other patients. A good level of control is defined as:
- no exacerbations during 6 months of followup (an exacerbation is defined as the
un-planned need for care that modifies the patient's prescription for >48h)
- FEV1 (forced expiratory volume in 1 second) value current / FEV1 best value > 0.8
- symptom levels correspond to an ACQ (Asthma Control Questionnaire) questionnaire score
of < 0.75 over the last 7 days
;
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