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NCT03118869 Clinical Trial

B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma

Asthma Clinical Trial

— polymorphism  

Official title:
B2adrenergic Receptor Gene Polymorphism in Bronchial Asthma: Relation to Disease Severity and Control

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT03118869
Other study ID # AssiutU3
Secondary ID
Status Active, not recruiting
Phase N/A
First received April 11, 2017
Last updated August 25, 2017
Start date April 1, 2017
Est. completion date October 30, 2017

Study information
Verified date August 2017
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.

The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.

Description:

Asthma is a complex disease and has a strong genetic component in its pathogenesis. So far, considerable efforts have been made to evaluate the association between genetic variants and asthma risk, and numerous genes have been identified as asthma Reporting Items susceptible genes.

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.

The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 75
Est. completion date October 30, 2017
Est. primary completion date October 1, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- patients diagnosed as asthma according to GINA guideline 2016.

- Allergic asthma

Exclusion Criteria:

- pneumonia

- chronic cardiac, hepatic and renal diseases

- pregnancy and lactation

- malignancy

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Egypt AssiutU Assiut

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary To measure number of patient with homozygous and heterozygous B2AD gene polymorphisms with focus on Arg/Gly16 and Gln/Glu27 polymorphism study of prevalence homozygote and heterozygote patients 1 month
Secondary Number of patient with b2AR gene polymorphisms in different asthma severity and different response of treatment of asthma ( Arg/Gly16 and Gln/Glu27 polymorphism) correlation between polymorphism and pulmonary function test and level of disease control 1 month
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