Asthma Clinical Trial
Official title:
Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects: Randomized, Double-blind, and Crossover Study
Contextualization: Exercise is a common triggers of bronchospasm in patients with asthma and
healthy subjects. To prevent these symptoms frequently they have to use Short-Acting
Beta2-Agonists. However, the cardiovascular effects of salbutamol during and after exercise
remain poorly known.
Objective: To evaluate the effect of salbutamol on heart rate and blood pressure during
exercise in patients with moderate or severe asthma and healthy individuals.
Methods: A randomized, double-blind, crossover study will be conducted which 13 individuals
with moderate or severe persistent asthma and 13 healthy individuals aged between 20 to 59
years.
Patients will perform a maximal effort test on 2 nonconsecutive days, with either 400mcg
Salbutamol or 4 placebo puffs. The order of use of placebo or salbutamol will be drawn.
During the protocol, heart rate, blood pressure, perception of exertion and peak expiratory
flow will be monitored.
n/a
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