Asthma Clinical Trial
Program： Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe
Asthma Aim：The early prediction of severe asthma, early intervention on the disease, reduce
the family and the national finance.
design:This study is a single center randomized controlled trial designed by the Department
of respiratory medicine, Xijing Hospital, as the main research unit.Compare the case
group(severe asthma group and mild-and-moderate asthma group) and control group(healthy
control group) by detecting the activity of MPO、NE、MMP-9 and ECP in the peripheral blood and
the activity of HDAC2 in PBMCs of patients.
case:60
Case selection:
Inclusion criteria: age 18-75 years old; diagnosis of asthma was clear; informed consent was
signed.
Exclusion criteria: poor compliance; cognitive ability is low; psychiatric disorders need to
be combined with psychotropic medication.
Application of SPSS 19 statistical software. Measurement data were expressed as mean ±
standard deviation.
First the data is normality tested and homogeneity of variance tested, according to the
measurement data of normal distribution by SNK single factor analysis of variance; does not
conform to the normal distribution of measurement data, using the Kruskal Wallis non
parametric test. P < 0.05 for the difference was statistically significant.
;
Observational Model: Case Control, Time Perspective: Prospective
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