Asthma Clinical Trial
Official title:
Evaluation of the Prevalence of Asthma in a Cohort of Children Born After In Vitro Fertilization (Aged 11-15) Compared With Spontaneously Conceived Children of the Same Age Range
Assisted Reproduction Technologies (ART) are increasingly being used worldwide as a result
of fertility decline likely caused by changes in both environment and social behaviour.
Considering this large usage, it is important to evaluate the potential risk on the health
of children conceived using ART.
According to the literature, children born after ART are more likely to be at higher risk of
health problems than spontaneously conceived ones. Interestingly, recent studies suggested
an increase of asthma prevalence in children conceived using In Vitro Fertilization (IVF).
The purpose of this study is to evaluate the prevalence of asthma in school adolescents from
a cohort of children born after In Vitro Fertilization (IVF), aged 11-15 years as compared
to a control group composed of the same age range spontaneously conceived individuals.
The expected outcome of this study will provide new information regarding these children to
ART professionals of and to their own families, by focusing on an age range (between 11 and
15 years) for which very little information is available to date.
The methodology is a comparative epidemiological survey, between children from a historical
cohort born after intraconjugal In Vitro Fertilization (singleton or twin) aged 11-15 years
and a control group recruited in schools after the agreement of Academic Inspection.
Parents of the two groups will be contacted either by phone calls or through written
information given in the schools. They will receive the questionnaire and an information
letter, once they give their agreement to be a part of the study.
Data collection will be conducted using two anonymous questionnaires. The first
questionnaire was built based on items proposed in the international Health Behaviour in
School-aged Children (HBSC) survey of the World Health Organization (WHO). The second
questionnaire will be sent to parents. It will focus on the pregnancy and it will be used to
adjust the analysis.
This study was submitted and approved by an Institutional Review Board in France (Comité de
Protection des Personnes Sud-Méditerranée II) on 11th September 2015.
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Observational Model: Case Control, Time Perspective: Prospective
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