Asthma Clinical Trial
Official title:
Validation of Structured Light Plethysmography: Pre- and Post- Bronchodilator Challenge
Validation of Structured Light Plethysmography (SLP) in patients with asthma, in patients with acute asthma; an observational study in healthy participants and during patients' clinical investigation of broncho-reversibility in the asthma groups.
A non-randomised observational study to validate Structured Light Plethysmography in three
groups of participants: those with stable asthma and those with acute asthma, who are
undergoing routine clinical investigation of broncho-reversibility using spirometry. We will
also observe a normal healthy group who will receive no clinical intervention. SLP data
capture and spirometry (as part of the patients clinical care) will be performed before and
after a Bronchodilator reversibility test which is part of the patients normal clinical care
(except in the normal healthy group where no bronchodilator will be given). The data
collected from this study will allow us to examine the effect of bronchodilators on breathing
patterns in these patients and also compare breathing patterns in asthma patients to those in
healthy individuals.
The participant will wear a plain white t-shirt. Alternatively, the measurement can be taken
on bare skin or with the participant (if female) wearing a plain material white bra. The
participant is asked to sit down on a chair or lie down with their neck in a neutral position
and their back as straight as possible in front of the SLP device (Thora-3Di, Pneumacare
Ltd). The projector is lined up to project the grid of light over the participant's chest and
upper abdomen. and will be instructed to perform a period of 5 minutes of tidal breathing,
They will otherwise be asked to remain as still as possible throughout the measurement.
During the sequence of breathing, thoracoabdominal wall movements will be captured by the
device.
participant on completion of their Bronchodilator Challenge within the Lung Function
Department or clinic
The SLP measurement is repeated on completion of their Bronchodilator reversibility test
within the Lung Function Department or clinic.
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