Adult Arm of DZL All Age Asthma Cohort (ALLIANCE)

Asthma Clinical Trial

— ALLIANCE  

Official title:

The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Adult Arm

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02419274
• Other study ID #: DZL-GHD-ERA
• Status: Recruiting
• Start date: March 2014
• Est. completion date: December 2030

Study information

• Verified date: October 2023
• Source: LungenClinic Grosshansdorf
• Contact: Thomas J Bahmer, MD
• Phone: +49 4102 601 2412
• Email: thomas.bahmer[@]uksh.de
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Deep Phenotyping of adult asthma patients:

• severity from mild to severe

• both atopic and non-atopic

• both childhood and adult onset

• both smokers and non-smokers

• corresponding pediatric cohort (Pediatric Arm of DZL All Age Asthma Cohort) with equivalent SOPs regarding collection of biomaterial and clinical data incl. lung function, further processing of biomaterial and further analyses

Description:

The clinical heterogeneity of asthma patients has been increasingly recognised within the last years. Recent studies and articles highlighted the idea of asthma not beeing a single disease but rather a unifying term for multiple phenotypes. Phenotype in this sense is defined as the combination of observable properties of an organism, that are produced by the interactions of a genotype and the environment. In contrast, endotype describes a specific underlying pathophysiological pathway. Linking asthma phenotypes and endotypes in a system biological approach is an important research goal in order to develop targeted therapy, especially for severe asthma.

The advantage the investigators' cohort provides is the collaboration with an equivalent pediatric cohort. In this setting questions regarding disease onset, exacerbation and chronicity can be posed and worked with in a comprehensive manner.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Est. completion date: December 2030
• Est. primary completion date: December 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• Proven Diagnosis according to current GINA Guideline (2014)

• Ability to read and understand German

• Ability to understand and agree to informed consent

Exclusion Criteria:

• History of respiratory tract infection within the last 4 weeks before inclusion

Related Conditions & MeSH terms

• Asthma

Locations

Country	Name	City	State
Germany	LungenClinic Grosshansdorf	Grosshansdorf

Sponsors (3)

Lead Sponsor	Collaborator
LungenClinic Grosshansdorf	German Center for Lung Research, Research Center Borstel

Country where clinical trial is conducted

Germany, 

References & Publications (2)

Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008 Sep 20;372(9643):1107-19. doi: 10.1016/S0140-6736(08)61452-X. — View Citation

Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012 May 4;18(5):716-25. doi: 10.1038/nm.2678. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Defining clinical asthma phenotypes by combining clinical, lung function and biomaterial data		2 years