Does Asthma Phenotype Have Impact on Disease Control

Asthma Clinical Trial

— Aperitif  

Official title:

Does Asthma Phenotype Have Impact on Disease Control - Can Detection of Inflammation and Hyper Responsiveness Ensure Stable Disease Faster

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01978678
• Other study ID #: Aperitif
• Status: Completed
• Start date: November 2012
• Est. completion date: January 2015

Study information

• Verified date: November 2013
• Source: Bispebjerg Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The application of biomarkers that are more closely associated with eosinophillic airway inflammation, such as measurements of FeNO level, cell count in induced sputum or bronchial reactivity could improve asthma control by better directing treatment. A systematic review and meta-analysis is to be conducted to assess the efficacy of tailoring asthma intervention on clinical symptoms compared with exhaled nitric oxide or induced sputum count.

Description:

AHR used as outcome

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: January 2015
• Est. primary completion date: January 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 15 Years to 100 Years

Eligibility

Inclusion Criteria:

• positiv mannitol

• asthma diagnose

Exclusion Criteria:

• other lung disease

Related Conditions & MeSH terms

• Asthma

Intervention

Drug:
• Pulmicort
ACQ and FeNO

Locations

Country	Name	City	State
Denmark	Department of Respiratory Medicine, L, Bispebjerg Hospital,	Copenhagen	NV
Denmark	Respiratory research unit, Bispebjerg University Hospital	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
Bispebjerg Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	the use of ACQ and miniAQLQ	Based on ACQ and FeNO	2 years
Primary	Control of asthma based on an algorithm	Based on ACQ and FeNO	2 years
Secondary	The use of NO and sputum cell count as a marker in asthma management	Based on ACQ and FeNO	2 years