Severe Asthma Research Program (SARP)- San Francisco Clinical Site

Asthma Clinical Trial

— SARP  

Official title:

Clinical and Molecular Phenotypes of Severe Asthma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01718197
• Other study ID #: SARP-SF
• Secondary ID: 5U10HL109146-04
• Status: Completed
• Start date: November 2012
• Est. completion date: March 1, 2021

Study information

• Verified date: June 2023
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The mission of SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time. The ultimate goal of these efforts is to promote better treatments for severe asthma.

Description:

The mission of the SARP is to improve the understanding of severe asthma to develop better treatments. The SARP will gain a better understanding of asthma and its endotypes, in children and adults, by defining the disease at the molecular and cellular levels in the context of the temporal phenotypic expression of the disease. To this end, the SARP investigators will utilize both mechanistic and evoked phenotype approaches to: 1) characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma, and 2) to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes and 3) compare these features over time.

This approach involves a shared longitudinal protocol conducted across all participating centers which includes common information on all SARP participants. Additionally, the SARP-SF has identified mechanistic research questions to be included in the shared longitudinal protocol. This will be explored through additional sample collections of sputum and fluids and biopsied tissue collected by bronchoscopy. Together, these longitudinal and mechanistic approaches will enable prediction of phenotype stability/fluctuation and pharmacologic responses and identification of novel, disease-modifying targets for treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 151
• Est. completion date: March 1, 2021
• Est. primary completion date: February 18, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Years and older

Eligibility

Inclusion Criteria:

• FEV1 bronchodilator reversibility =12% or airway hyperresponsiveness reflected by a methacholine PC20 =16 mg/mL

• An exception will be made for enrollees whose FEV1 is < 50% predicted (<70% in children aged 6 to 17 years), precluding methacholine challenge testing. If bronchodilator reversibility is <12% in these participants, a diagnosis of asthma acceptable to the investigator is sufficient for inclusion in SARP.

Exclusion Criteria:

• Pregnancy during the characterization phase,

• Current smoking,

• Smoking history > 10 pack years if =30 years of age, or smoking history > 5 pack years if <30 years of age,

• Other chronic pulmonary disorders associated with asthma-like symptoms, including (but not limited to) cystic fibrosis, chronic obstructive pulmonary disease, chronic bronchitis, vocal cord dysfunction (that is the sole cause of respiratory symptoms and at the PI's discretion), severe scoliosis or chest wall deformities that affect lung function, or congenital disorders of the lungs or airways,

• History of premature birth before 35 weeks gestation,

• Unwillingness to receive an intramuscular triamcinolone acetonide injection

• Evidence that the participant or family may be unreliable or poorly adherent to their asthma treatment or study procedures,

• Planning to relocate from the clinical center area before study completion,

• Any other criteria that place the subject at unnecessary risk according to the judgment of the Principal Investigator and/or attending physician(s) of record, or

• Currently participating in an investigational drug trial.

Healthy Controls:

Inclusion criteria: Healthy subjects between the age of 18y and 65y. At least 3 of the 7 subjects per center should be aged 35y or older.

Exclusion criteria

• History of chronic diseases that affect the lungs.

• A history suggestive of allergic rhinitis, eczema or chronic sinusitis.

• An improvement in FEV1 of more than 12% following 4 puffs of albuterol.

• Smoking history > 10 pack years if =30 years of age, or smoking history > 5 pack years if <30 years of age, or any smoking within the past year.

• Respiratory tract infection within the past 4 weeks.

• Pregnancy.

• History of premature birth (<35 weeks).

Related Conditions & MeSH terms

• Asthma

Locations

Country	Name	City	State
United States	University of California, San Francisco	San Francisco	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, San Francisco	National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lung function decline	Changes in lung function parameters over time.	Enrollment, 1 year, 2 years, 3 years
Secondary	Exacerbation frequency	Number of oral corticosteroid requiring exacerbations of asthma	Monthly for 3 years
Secondary	Inflammatory cellular markers	Changes in inflammatory cellular markers in sputum, exhaled breath, and blood.	Enrollment, 1 year, 2 years, 3 years

External Links

•   Severe Asthma Research Program Main Webpage
•   UCSF Recruitment Website