Asthma Clinical Trial
Official title:
Effect of Intranasal Corticosteroids on Pulmonary Symptoms in Asthmatics With Nasal Congestion, a Randomized Controlled Trial
In this study we will investigate the effect of intranasal corticosteroid therapy, which is known to reduce mucosal inflammation and nasal blockage, on asthmatic symptoms.
Although up to 95% of asthma patients suffer from blocked nose, the majority of these
patients do not undergo systematic assessment and treatment for nasal blockage. This is
unfortunate, as optimal diagnosis and treatment of nasal blockage in asthmatics can reduce
asthma morbidity and use of anti-asthmatic medication.
The "Unified Airways" concept considers the upper and lower airways as one unified airway.
In recent years there has been increasing awareness about the relationship between
inflammation in the upper and lower airways, with disease in the upper airways affecting the
lungs through neurological, immunological and mechanical mechanisms, resulting in asthmatic
symptoms.
Conditioning and filtration of the inspired air are important functions of the nose, and
oral breathing results in inhalation of poorly conditioned and filtered air in to an already
inflamed lower airway. Together will these mechanisms lead to a worsening of the asthmatic
disease.
The aim of this study is to investigate the effect of intranasal corticosteroid therapy,
which is known to reduce mucosal inflammation and nasal blockage, on asthmatic symptoms. The
primary outcome variable is improvement in asthma symptomatology. The secondary outcome
variables are improvement in nasal blockage.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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