Asthma Clinical Trial
Official title:
The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma
The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.
Chitinase 3-like 1 (CHI3L1) is a member of human chitinases family. According to previous
studies in literatures, increased expression of CHI3L1 has been proven to be correlated with
the presence of different diseases, including cancers, autoimmune diseases, and chronic
inflammatory conditions. Elevated serum levels of YKL-40 are associated with increased
disease severity, poorer prognosis and shorter survival for many other diseases. When
monitored over time, increases in serum YKL-40 parallel with disease progression. It can
serve as an measurable marker of changes in disease status.
There were indicated that chitinase 3-like 1 might be associated with some clinical
diseases. The C-allele of the -131 C→G (rs4950928) polymorphism of CHI3L1 has been shown to
associate with bronchial hyperresponsiveness and reduced lung function. It is suggesting
that variations in CHI3L1 may influence risk of asthma.
The objective of this study was to investigate the relationship between single nucleotide
polymorphism of chitinase 3-like 1 and human asthma. The association between CHI3L1 SNPs and
the continuous outcomes were examined by real time PCR and gene sequencing analysis.
In Korean reports there was no significant associations between CHI3L1 SNPs and asthma were
observed. On the other hand, there were association between CHI3L1 and asthma observed in
the majority of Caucasian populations. However, similar research has not been conducted in
Taiwan. In contrast to preliminary studies, the investigators predict the rs4950928 G
allele, and not the C allele, was found to be associated with asthma. The g.-247C/T
polymorphism in the CHI3L1 promoter region is associated with the risk of atopy.
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Observational Model: Case Control, Time Perspective: Retrospective
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