Asthma Clinical Trial
Official title:
Nasal Features of Subjects With Nasal Polyposis With or Without Asthma
Background: Nasal polyps are found in about 5% of asthmatic patients.A close link exists
between the upper and lower airways and the concept of the "United Airways" has emerged
mainly from studies on allergic rhinitis and asthma. However, other upper airway diseases,
such as chronic sinusitis and nasal polyposis may influence lower airway diseases. As for
nasal polyposis, eosinophils are the major effector cells in asthma and have been associated
with a worsening of this condition.
Aim: To compare normal nasal mucosa and nasal polyp biopsies from subjects with nasal
polyposis with or without asthma.
Hypothesis: Nasal polyps from asthmatic subjects show a more aggressive pro-inflammatory
pattern of cytokine expression compared to nasal polyps from non asthmatic subjects, and
therefore contribute to the development and severity of asthma.
The study will include 2 visits separated by a maximum of 7 days. During the first visit, subjects' characteristics will be documented by a locally validated questionnaire. Allergy skin prick tests, spirometry, methacholine inhalation test and induced sputum will also be done. Asthma and rhinitis control will be evaluated by locally validated questionnaires, the Asthma Control Scoring System (ACSS) and the Rhinitis Control Scoring System (RCSS), respectively. Nasal peak inspiratory flow (NPIF) and oral peak expiratory flow (PEF) will also be recorded to obtain the nasal blockage index (NBI). On the second visit, nasal biopsies will be taken. ;
Observational Model: Case Control, Time Perspective: Prospective
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