Asthma Clinical Trial
Official title:
Pharmacogenetics of b2-Agonists in Asthma.
This study will help to find out if having a certain genetic makeup influences how a person with asthma responds to salmeterol, one of the two drugs in Advair(R).
Patients are being asked to take part in this research study because they have asthma. This
clinical research study is being done to see if an asthmatic's gene make-up (DNA is made up
of genes) affects the way they respond to a particular asthma medication called salmeterol.
Certain genes make people tall or short. Certain genes give people brown or black hair.
Similarly, certain genes may be associated with the way patients respond to asthma
medications.
Salmeterol xinafoate (a long acting bronchodilator) and fluticasone propionate (an inhaled
corticosteroid) are the medicines contained in Advair Diskus. During this study, patients
with asthma will receive fluticasone inhaler (called Flovent) and Advair Diskus. The
investigators want to find out if patients with asthma with certain genes respond in
different ways to the salmeterol in Advair Diskus. The investigators also want to find out if
patients with asthma with certain genes who are treated with salmeterol for two weeks have
their airways open up less than usual when they use albuterol.
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