Asthma Clinical Trial
Official title:
A Pilot Study to Evaluate the Dose-response of Inhaled Formoterol to Inhibit Airway Responsiveness to Methacholine in Patients With Mild Asthma
The purpose of this study is to find out whether a difference between two doses of formoterol can be detected by methacholine challenge.
During the screening visit, subjects'vital signs (heart rate, blood pressure and
temperature) will be measured and they will perform standard spirometry. If the results of
this test are 70% of normal or greater, they will be examined by a physician, and blood (1
teaspoonful) and urine will be collected for routine laboratory tests (CBC and routine
urinalysis). If they are a female, a pregnancy test will be performed.
During the second visit, subjects will inhale 1 or 2 doses of formoterol, (Foradil Aerolizer
12 mcg/capsule) a long-acting bronchodilator and 1 hour later, perform a methacholine test.
At the end of the methacholine test, they will be given albuterol to reverse the effects of
methacholine. On the third study day, they will repeat the second visit but with the
opposite dose of Foradil.
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Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label
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