Study to Evaluate the Impact of Obesity on Airway Inflammation and Mechanics in Asthmatics

Asthma Clinical Trial

— ABI/BALA  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00615706
• Other study ID #: 345-2004
• Secondary ID: Emory IRB ID 345
• Status: Completed
• Phase: N/A
• First received: February 4, 2008
• Last updated: September 22, 2008
• Start date: January 2005
• Est. completion date: September 2008

Study information

• Verified date: September 2008
• Source: Emory University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

In the United States there has been a dramatic increase in the number of people who are obese and in the number of people who have asthma. Both are considered serious public health concerns. Several studies have shown that becoming obese or overweight can increase the risk of developing asthma or can make asthma symptoms more severe and difficult to control. How obesity affects asthma is not fully understood. This research study will examine whether obesity affects the amount of inflammation that is present in the lungs of people with asthma, and will also examine whether obesity leads to narrow and stiff airways.

Participation in this study involves 2 visits in order to complete questionnaires, various pulmonary function tests, as well as the collection of blood, urine, and exhaled breath condensate specimens.

This research study includes optional genetic and bronchoscopy substudies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: September 2008
• Est. primary completion date: September 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Adults 18 to 70 years of age

• If asthmatic, currently taking a short acting beta agonist and an inhaled corticosteroid

• Never smoked or limited smoking history

Exclusion Criteria:

• Current upper respiratory illness (other than asthma)

• Illegal drug use within past month

• Consumption of more than 6 alcoholic drinks per week

• Active, pronounced rhinitis or sinusitis

• Pregnancy

• Currently taking oral steroids or steroid injection over the past month

• Asthma exacerbation over the past month

• Certain medical illnesses

Study Design

Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Asthma

Intervention

Other:
• No intervention
no intervention

Locations

Country	Name	City	State
United States	Emory University, Emory Crawford Long Hospital, Clinical Research Center	Atlanta	Georgia

Sponsors (2)

Lead Sponsor	Collaborator
Emory University	Critical Therapeutics

Country where clinical trial is conducted

United States,