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NCT00613587 Clinical Trial

Roflumilast In-Vitro Basophil Release

Asthma Clinical Trial

Official title:
Effect of Roflumilast In-Vitro on Basophil Histamine, Leukotriene, IL-4 and IL13-release.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00613587
Other study ID # RGT2007
Secondary ID
Status Completed
Phase N/A
First received January 30, 2008
Last updated October 8, 2012
Start date August 2007
Est. completion date January 2010

Study information
Verified date September 2012
Source Creighton University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

This study is looking for allergic asthmatics. Lung and allergy testing will be done to verify. If qualified, blood will be drawn for laboratory studies.

Description:

Non-smoking allergic asthmatics will be verified using pulmonary function, skin prick testing, exhaled nitric oxide and serum IgE. If qualified, blood will be drawn, treated with study medication and then stimulated with the allergen to which the subject is allergic. Mediators including Histamine, IL-13, IL-4, and leukotrienes will be measured.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date January 2010
Est. primary completion date January 2010
Accepts healthy volunteers No
Gender Both
Age group 19 Years to 65 Years
Eligibility Inclusion Criteria:

- Age 19 and above Allergic Asthma Serum IgE greater than 30iu/ml Exhaled Nitric Oxide greater than 17ppb

Exclusion Criteria:

- smoking history

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States Creighton University Medical Center Omaha Nebraska

Sponsors (2)
Lead Sponsor Collaborator
Creighton University Takeda

Country where clinical trial is conducted

United States, 

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