Asthma Clinical Trial
Official title:
The Effect of Beta-2 Adrenergic Polymorphisms on the Bronchoprotective Effects of Regular Salmeterol Treatment in Asthma
The purpose of the study is to find out how well a long-acting beta agonist like salmeterol works in people with different forms of the same gene. Our hypothesis is that asthmatics with the Arg/Arg genotype will have loss of bronchoprotection against exercise-induced asthma with regular salmeterol treatment, as compared to asthmatics with the Gly/Gly genotype.
In many patients with asthma, exercise-induced bronchoconstriction is a common and
oftentimes limiting characteristic. Inhaled β2-adrenoreceptor agonists like albuterol are
the most effective treatments available for the relief of acute asthma symptoms. However,
there is evidence that regular use may lead to adverse effects in some patients. Previous
studies have shown that polymorphisms of the β2-adrenergic receptor can influence airway
responses to regular inhaled beta-agonist treatment.
Pharmacogenetics is the study of how genetic differences influence the variability in
patients' responses to therapy, both therapeutic and adverse. Genetic susceptibility and
environmental factors both play major roles in the etiology of asthma. The strong familial
clustering of asthma has lead to a surge of research into the genetic predisposition of
asthma. The aim of the present study is to utilize a double-blinded prospective cohort study
to investigate whether genotype-specific effects occur when assessing the duration of
protection conferred against exercise-induced bronchoconstriction by regular salmeterol
treatment.
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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