Childhood Origins of Asthma (COAST)

Asthma Clinical Trial

— COAST  

Official title:

Rhinovirus Infection and Asthma in Childhood and Adolescents

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00204841
• Other study ID #: 1998-129
• Secondary ID: P01HL0708312013-
• Status: Completed
• Start date: October 1998
• Est. completion date: June 30, 2019

Study information

• Verified date: July 2019
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.

Description:

No more description necessary.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 287
• Est. completion date: June 30, 2019
• Est. primary completion date: June 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 2 Minutes

Eligibility

Inclusion Criteria:

• children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

• pre term infants

• low birth weight infants

• respiratory distress at birth

Related Conditions & MeSH terms

• Allergy
• Asthma

Locations

Country	Name	City	State
United States	University of Wisconsin	Madison	Wisconsin

Sponsors (3)

Lead Sponsor	Collaborator
University of Wisconsin, Madison	National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluate the children longitudinally for the inception and progression of asthma.	Clinical diagnosis of childhood asthma at age 6 years and older.	Birth through age 19

External Links

•   study web page