Asthma Clinical Trial
Official title:
Evaluation of Genetic Factors That May Account for Variability in the Response to Salbutamol Among Patients Suffering From Asthma
The response to salbutamol varies greatly among individuals. Data from previous studies
indicate that some of the variability is accounted for by genetic polymorphisms in the gene
encoding for the adrenoceptor subtype β2. The current study was designed to evaluate
variability in the response to salbutamol among recently diagnosed patients who have not
been treated by β2 agonists or corticosteroids.
Lung function tests will be performed prior to and following a single dose administration of
salbutamol through inhalation. Additional pharmacodynamic indices will be monitored
including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation
of salbutamol plasma concentration.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label
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