CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Asthma Clinical Trial

Official title: CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Status Recruiting

Clinical Trial Summary

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

Clinical Trial Description

This study aims to prove that emerging CT-based tools are suitable to measure changes in central and peripheral bone density, geometry, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids. To do this, investigators will recruit 10 non-smokers (defined as < 10 pack-year smoking history) age 25-45 years with a diagnosis of severe, persistent asthma who either chronically use oral steroids or do not use any oral steroids. Participants will undergo dual-energy X-ray absorptiometry (DXA), dual-energy mid-tibia CT, high-resolution single-energy ankle CT, and low-radiation hip CT scans at baseline and 6-month follow-up visits. The images obtained will be used to analyze cross-sectional differences in central and peripheral bone density, geometry, micro-structure, and MAT between patients using oral steroids versus those who do not use any oral steroids. Differences in imaging at baseline and six-month follow visits will be used to analyze longitudinal bone changes among patients with oral steroid treatment. ;

Related Conditions & MeSH terms

• Asthma
• Bone Density, Low
• Bone Diseases, Metabolic
• Oral Steroid-Dependent Asthma (Disorder)

• NCT number: NCT04518722
• Study type: Observational
• Source: University of Iowa
• Contact: Taylor M Haynes, MS
• Phone: 319-356-1785
• Email: taylor-haynes@uiowa.edu
• Status: Recruiting
• Start date: December 1, 2020
• Completion date: September 1, 2025