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NCT05850143 Clinical Trial

EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD

Asthma in Children Clinical Trial

Official title:
EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT05850143
Other study ID # ERB/SZABMU/2021-192
Secondary ID
Status Enrolling by invitation
Phase N/A
First received
Last updated
Start date January 26, 2019
Est. completion date December 26, 2023

Study information
Verified date April 2023
Source Shaheed Zulfiqar Ali Bhutto Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 192
Est. completion date December 26, 2023
Est. primary completion date December 26, 2023
Accepts healthy volunteers No
Gender All
Age group 2 Years to 12 Years
Eligibility Inclusion Criteria: - i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6 Exclusion Criteria: - i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Dexamethasone
Oral Dexamethasone a longer and potent corticosteroid with lesser sideffects and good compliance
• Prednisolone
Oral Multidose Prednisolone

Locations
Country Name City State
Pakistan Asim Nawaz Niazi Islamabad

Sponsors (1)
Lead Sponsor Collaborator
DR. MOHAMMAD ALI ARIF

Country where clinical trial is conducted

Pakistan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Improvement in PRAM score PRAM will be evaluated at day 4 4 days
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