Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

Asthma, Exercise Induced Clinical Trial

Official title:

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00710255
• Other study ID #: CHRMS 08-023
• Secondary ID: Merck IISP 32710
• Status: Completed
• Phase: N/A
• First received: July 2, 2008
• Last updated: October 27, 2016
• Start date: October 2007
• Est. completion date: July 2009

Study information

• Verified date: October 2016
• Source: University of Vermont
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: July 2009
• Est. primary completion date: March 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 12 Years to 75 Years

Eligibility

Inclusion Criteria:

• Physician diagnosed asthma

• Age 12-75 yrs

• FEV1 > 70% predicted

• HIB response > 10 %

• No smoking last 6 mo and < 10 pack yrs

• No URI last 4 weeks

• No asthma exacerbation last 4 weks

• Able to withhold SABA > 8 hrs and LABA > 24 hrs

Exclusion Criteria:

• Other lung disease

• Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma, Exercise Induced
• Asthma, Exercise-Induced
• Bronchial Spasm

Intervention

Procedure:
• Hyperpnea challenge
5 minutes of dry air hyperpnea to induce bronchospasm

Locations

Country	Name	City	State
United States	Vermont Lung Center	Colchester	Vermont

Sponsors (1)

Lead Sponsor	Collaborator
University of Vermont

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in level of cystLTs and adenosine		Before and after hyperpnea challenge	No
Secondary	Change in pH of EBC and change in pulmonary function		Before and after hyperpnea challenge	No