Retrospective Study of Patients With Acute Presentation for Asthma to an Emergency Department in UK (RAPAE)

Asthma Acute Clinical Trial

— RAPAE  

Official title:

Retrospective Study Investigating the Clinical Characteristic of Patients With Acute Presentation for Asthma to the A+E Department in a Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between January 2019 and January 2024

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06360185
• Other study ID #: Asthma V2 October 2023
• Status: Not yet recruiting
• Start date: May 1, 2024
• Est. completion date: December 1, 2025

Study information

• Verified date: March 2024
• Source: Norfolk and Norwich University Hospitals NHS Foundation Trust
• Contact: Sadiyah Hand, FRPC
• Phone: 01603 289612
• Email: sadiyah.hand[@]nnuh.nhs.uk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.

Description:

1. How many previous admissions in past one year (12 months)

2. How many presentations to A+E in previous one year (12 months)

3. Diagnosis not confirmed therefore not on any ICS

4. Poor compliance (less than 75% of ICS and/or LABA and/or LAMA and/or leukotriene prescriptions picked up in past year)

5. Recent presentation and maintenance therapy not increased (primary care or secondary care issue)

6. Is patient overweight BMI

7. Is patient on hormonal therapy, OCP, HRT, male hormones

8. Social class quintile from post code of address using ONS calculator

9. Ethnically diverse (see appendix)

10. First Eosinophil count on index admission

11. Highest eosinophil count in past (ever) and date

12. Treatment for diabetes type 2

13. Treatment for diabetes type 1

14. Treatment for hypertension

15. Smoker ever (pack year) when gave up__________

After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to A+E. They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy, especially if they have raised eosinophils in the past year.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 400
• Est. completion date: December 1, 2025
• Est. primary completion date: December 1, 2025
• Gender: All
• Age group: 16 Years to 99 Years

Eligibility

Inclusion Criteria:

• All Asthmatics patients who attend Emergency department over 5 years

Exclusion Criteria:

• None Asthmatics.

Related Conditions & MeSH terms

• Asthma
• Asthma Acute

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Norfolk and Norwich University Hospitals NHS Foundation Trust

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in body weight	Information will be taken from hospital documentation and from GP records.	5 years
Primary	Change in body height	Information will be taken from hospital documentation and from GP records.	5 years