The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index

Asthenozoospermia Clinical Trial

Official title:

The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index and Thiol Related Enzymes in Spermatozoa of Iraqi Asthenospermic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02985905
• Other study ID #: Babil-4
• Status: Completed
• Phase: Phase 2
• First received: December 2, 2016
• Last updated: December 6, 2016
• Start date: July 2011
• Est. completion date: July 2012

Study information

• Verified date: December 2016
• Source: Babylon University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Iraq: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.

Description:

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: July 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 26 Years to 36 Years

Eligibility

Inclusion Criteria:

• The presence of asthenozoospermia in the semen sample.

Exclusion Criteria:

• The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Asthenozoospermia

Intervention

Dietary Supplement:
• zinc sulfate
The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Locations

Country	Name	City	State
Iraq	Mahmoud Hadwan	Hilla	Babylon

Sponsors (2)

Lead Sponsor	Collaborator
mahmoud hussein hadwan	Ministry of Health, Iraq

Country where clinical trial is conducted

Iraq, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels.		up to three months.	Yes
Secondary	Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels.		up to three months.	Yes
Secondary	Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels.		up to three months.	Yes