Asthenozoospermia Clinical Trial
Official title:
Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway
The ability of spermatozoa to produce reactive oxygen species (ROS) has been respected since the 1940's. Oxidative stress limits the functional competence of mammalian spermatozoa via lipid peroxidation, the induction of oxidative DNA damage and the formation of protein adducts. Nitric oxide (NO) is a free radical generated from the oxidation of L-arginine to L-citrulline by reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent NO synthases. Several studies suggest that the overproduction of this free radical and the subsequent excessive exposure to oxidative conditions have a potential pathogenetic implication, which due to the reduction of sperm motility. The present study was conducted to study the effect of Zn supplementation on the levels of NO synthase and arginase in semen of patients with asthenozoospmia.
Previous studies suggest that high concentrations of NO play an injurious consequence on spermatozoa kinetic characteristics. These studies reported that NO may react with superoxide or hydrogen peroxide, resulting in the production of peroxinitrite, hydroxyl radical, or singlet oxygen, which cause oxidation of sperm membrane lipids and thiol proteins. NO also may inhibit cellular respiration by nitro-sylation of heme in mitochondrial enzymes, aconitase, and glyceraldehyde phosphate dehydrogenase, leading to a reduction of adenosine triphosphate and that is due to loss of motility of spermatozoa. ;
Observational Model: Case Control, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05506722 -
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
|
N/A | |
| Completed |
NCT04291495 -
Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential
|
N/A | |
| Recruiting |
NCT05826782 -
Effect of Antioxidant Food Supplement on Sperm Proteomic Structure and Semen Parameters
|
N/A | |
| Completed |
NCT01954498 -
Effect of Walnuts on Sperm Parameters and Male Fertility
|
N/A | |
| Not yet recruiting |
NCT05792813 -
Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility
|
Early Phase 1 | |
| Recruiting |
NCT01856361 -
Ramipril for the Treatment of Oligospermia
|
N/A | |
| Completed |
NCT02217189 -
Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers
|
Phase 2 | |
| Completed |
NCT01612403 -
Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen
|
N/A | |
| Completed |
NCT02985905 -
The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index
|
Phase 2 | |
| Recruiting |
NCT03183999 -
Effect of Fermented Ginseng (GINST) on Sperm Motility
|
N/A | |
| Completed |
NCT03463005 -
The Effect of Royal Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-fertility Husbands
|
N/A | |
| Recruiting |
NCT05628987 -
The Association of Gut Microbiota and Spermatogenic Dysfunction
|
||
| Completed |
NCT01846325 -
The Effects of Administration of Combined Docosahexaenoic Acid and Vitamin E Supplements on Spermatogram and Seminal Plasma Oxidative Stress in Infertile Men With Asthenozoospermia
|
Phase 2/Phase 3 | |
| Completed |
NCT01828710 -
Myo-inositol on Human Semen Parameters
|
N/A | |
| Recruiting |
NCT05328999 -
Fertility and the Microbiome
|
||
| Not yet recruiting |
NCT05436080 -
Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level
|