Asthenozoospermia Clinical Trial
Official title:
Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway
Verified date | September 2012 |
Source | Babylon University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Iraq: Ethics Committee |
Study type | Observational |
The ability of spermatozoa to produce reactive oxygen species (ROS) has been respected since the 1940's. Oxidative stress limits the functional competence of mammalian spermatozoa via lipid peroxidation, the induction of oxidative DNA damage and the formation of protein adducts. Nitric oxide (NO) is a free radical generated from the oxidation of L-arginine to L-citrulline by reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent NO synthases. Several studies suggest that the overproduction of this free radical and the subsequent excessive exposure to oxidative conditions have a potential pathogenetic implication, which due to the reduction of sperm motility. The present study was conducted to study the effect of Zn supplementation on the levels of NO synthase and arginase in semen of patients with asthenozoospmia.
Status | Completed |
Enrollment | 60 |
Est. completion date | July 2012 |
Est. primary completion date | July 2012 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 27 Years to 35 Years |
Eligibility |
Inclusion Criteria: - the presence of asthenozoospermia in the semen sample. Exclusion Criteria: - the absence of endocrinopathy, - varicocele, and - female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels |
Observational Model: Case Control, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
Iraq | Babylon university/ college of science | Hilla |
Lead Sponsor | Collaborator |
---|---|
Babylon University | Ministry of health/Iraq |
Iraq,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Nitric oxide synthase activity | at the end of three months | Yes | |
Secondary | Arginase activity | at the end of three months | Yes |
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