Asherman's Syndrome Clinical Trial
Official title:
New Therapeutic Approaches to Treat Asherman's Syndrome and Endometrial Atrophy Based in BM Stem Cells Autologous Transplantation
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
This novel technique refers to the use of CD133+ autologous bone marrow stem-cells to
regenerate the endometrium in patients with Asherman's Syndrome, Endometrial Atrophy or any
condition that produce a destruction of the endometrium or its de novo creation in a
bioengineered uterus.
It requires a previous mobilization in the peripheral blood of CD133+ autologous bone marrow
stem cells, subsequent apheresis and transplant of the same cells in the spiral arterioles
of the uterus with the aim to regenerate de novo the endometrium. This technique represents
a new therapeutical approach for the treatment of endometrial regeneration problems such
Asherman Syndrome and the endometrial atrophy since currently no specific treatment for
these endometrial pathologies exist.
A prospective experimental non controlled study has been designed in order to assess the
effectiveness of these technique as a new tool for treat Asherman's Syndrome and Endometrial
Atrophy.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03223454 -
Human Amniotic Epithelial Cells for Asherman's Syndrome
|
Phase 1 | |
| Terminated |
NCT02825849 -
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
|
Phase 2 | |
| Recruiting |
NCT06450301 -
Senescent Endometrial Cells in Patients With Thin Endometrial Lining
|
||
| Completed |
NCT02708277 -
Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions
|
N/A |