Arthroplasty, Replacement, Knee Clinical Trial
Official title:
COPE: Cannabinoids to Obviate Pain Experiment After Knee Replacement
Total knee replacement is a major and painful orthopaedic (joint and bone) surgery where the
knee joint is replaced with an artificial joint. It is an effective and successful procedure
to treat severe knee arthritis and reduce pain, but many patients report intense pain after
the surgery.
Postoperative pain control is predominated by opioids (morphine-based drugs). While opioids
are effective to manage the pain, they can have acute and chronic complications, including
confusion, nausea, vomiting, constipation and high risk of addiction.
Medical cannabis is an effective and safe alternative for pain treatment. Recent studies
showed that patients have reported a reduction in opioid usage when taking cannabis as a
substitute for pain relief.
This study aims to investigate whether adding medical cannabis (cannabidiol - CBD) treatment
will decrease the amount of opiates needed in the first 2 weeks after knee replacement
compared to a group given placebo.
COPE (Cannabinoids to Obviate Pain Experiment after knee replacement) will be a
single-centre, prospective, randomized, placebo-controlled, superiority trial, with two
parallel groups designed to investigate the effect of cannabis as postoperative pain
treatment compared to placebo on total opioid consumption after total knee replacement.
Eligible patients are: men and non-pregnant women aged ≥18 years scheduled to undergo primary
total knee replacement. and with no opioid usage within the last 3 months or history of
narcotic abuse.
Patients will be recruited at the department of orthopaedic surgery at St Michael's Hospital
(Toronto - Canada), and informed consent will be obtained from those eligible. Central
computer-generated randomization will be used to randomly assign participants to cannabis or
placebo groups (1:1 ratio). Only the study pharmacist will know allocated treatments.
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