Arthritis of Knee Clinical Trial
Official title:
Blood Levels of Local Anaesthetic in Knee Arthroplasty: A Pharmacological Study of Ropivacaine Blood Levels During the Caledonian Technique for Knee Arthroplasty
The primary goal is to evaluate ropivacaine blood concentrations during and after local
anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee
replacement surgery. The investigators plan to measure these levels by testing blood samples
taken over a timed period.
This will allow us to confirm whether the current regimen of local anaesthetic use is within
safe limits.
Local anaesthetic (LA) toxicity may occur when the blood levels of a drug become
particularly high. There is a need to confirm that the technique is safe to use. In
addition, journal case reports may only describe serious side-effects of toxicity such as
abnormal heart rhythms whilst more subtle clinical signs are rarely reported.
The investigators would like to study whether or not toxic levels may be approached in some
patients or whether more subtle toxicity symptoms and signs are missed. For example,
irregular heartbeat, low blood pressure or confusion/agitation.
Therefore, the investigators intend to study ropivacaine blood levels in patients receiving
a total knee replacement in the Golden Jubilee National Hospital. A series of timed samples
will be taken during the perioperative period. The anaesthesia and surgery will be performed
as routine and no new treatment will be involved. Patient demographics, ropivacaine blood
levels and clinical observations following LA administration will be collected.
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Observational Model: Case-Only, Time Perspective: Prospective
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