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Arthralgia Generalized clinical trials

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NCT ID: NCT03811509 Recruiting - Osteoporosis Clinical Trials

Breast Cancer Women on Aromatase Inhibitors Treatment

B-ABLE
Start date: January 1, 2016
Phase: Phase 4
Study type: Interventional

The main objective of the study is to improve the life quality of women treated with AI. Cohort B-ABLE is designed to evaluate musculoskeletal events derived of using AI in breast cancer women. The project objectives are the analysis of the AI deleterious effect on bone microarchitecture and early determination of the risk of fragility fracture with dual energy x-ray absorptiometry (DEXA), lumbar spine Rx, Trabecular Bone Score (TBS) and microindentation. Determination of physiological causes of the AI-related arthralgia by analyzing joint degradation markers, steroid hormone levels remaining in blood and functional magnetic resonance, before and after three months of AI treatment