Clinical Trials Logo

Clinical Trial Summary

The investigators present a weight loss diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to assess interaction of non-nutritive sweetener (sucralose) with a high-fibre weight loss diet, on markers of gut health in humans. This study will allow assessment of the effects of a non-nutritive sweetener (sucralose) with a high-fibre (soluble fibre, fructo-oligosaccharides, FOS) diet on metabolic health and activity and composition of gut microbiota, by a controlled human diet intervention study. The investigators propose to recruit participants living with obesity, with a poor diet quality (moderate habitual fibre intake) to additionally address diet inequalities in the research approach, and this will also allow examine the time-course of adaptation of the gut microbiome (measured in faecal samples). The investigators will also assess changes in free-living glycaemic control with addition of dietary fibre and bio-markers of health.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05892003
Study type Interventional
Source University of Aberdeen
Contact Alexandra Johnstone, Prof
Phone 01224 438614
Email alex.johnstone@abdn.ac.uk
Status Recruiting
Phase N/A
Start date May 12, 2023
Completion date December 2024

See also
  Status Clinical Trial Phase
Completed NCT05702372 - Acute Glycemic Effects of Crackers Made by Different Flours N/A
Recruiting NCT06015490 - The Impact of the Physiological Response to Sugar on Brain Activity and Behavior N/A
Completed NCT06163937 - Acute Effects of Fruit Juices Consumption on Postprandial Glycemic Responses and Satiety N/A
Completed NCT05815641 - Pre- and Post-prandial Levels of Appetite Regulatory Hormones in Adults N/A
Completed NCT04831268 - Effects of Traditional Greek Meals on Glycemic Responses N/A
Completed NCT03783390 - Brain, Appetite, Teens, and Exercise N/A
Active, not recruiting NCT03232008 - Canderel:Effects on Blood Glucose Concentration and Appetite Scores N/A
Recruiting NCT06108128 - Food for Thought: Executive Functioning Around Eating Among Children N/A
Completed NCT05702307 - Determining the Glycemic Effects of Sunflower Pasta N/A
Completed NCT05197283 - Determining the Glycemic Effects of Three Types of Spaghetti N/A
Completed NCT03409484 - Effects of Concord Grape Juice Alone on Glycemia, Appetite and Cognitive Function in Healthy Adults N/A
Active, not recruiting NCT05618756 - CBD, Nutrient Metabolism and Energy Intake N/A
Completed NCT06146322 - Barley Beta-glucan, Glycemic Control, and Appetite N/A
Completed NCT03550339 - Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss N/A
Completed NCT05507801 - Protein and Satiety in Older Adults (PROSAT) N/A
Completed NCT03636217 - Effect of Kefir on Appetite N/A
Completed NCT05349903 - Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis N/A
Completed NCT04240795 - Effect of Lubricity of Food Gels on Satiation and Satiety N/A
Completed NCT04866875 - Investigating the Early Markers of Weight Loss N/A
Recruiting NCT04623450 - Macronutrients and Satiety in Older and Younger Adults N/A