An fMRI Study of Satiation in Healthy Volunteers.

Appetite Clinical Trial

Official title:

Satiation Attenuates BOLD Activity in Brain Regions Involved in Reward and Increases Activity in an Inhibitory Control Area: an fMRI Study in Healthy Volunteers.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02298049
• Other study ID #: UBirmingham
• Status: Completed
• Phase: N/A
• First received: November 19, 2014
• Last updated: November 20, 2014
• Start date: July 2010
• Est. completion date: December 2010

Study information

• Verified date: November 2014
• Source: University of Birmingham
• Contact: n/a
• Is FDA regulated: No
• Health authority: National Research Ethics Service United Kingdom':'
• Study type: Interventional

Clinical Trial Summary

To our knowledge no study has assessed the effects of a meal on neural responses to food cues and compared this with a condition simulating natural inter-meal hunger levels. This is important, as the existing literature often compares the effect of fasting to satiation, which may not reflect typical appetite processes. Thus, the purpose of this research was to examine the effect of a satiating lunch compared to a normal pre-meal state on blood oxygen level dependent (BOLD) activity in the human brain, as measured using functional magnetic resonance imaging (fMRI).

Description:

We hypothesized that satiation would be associated with decreased brain activity across brain regions involved in both appetite and reward such as ventromedial prefrontal cortex, orbitofrontal cortex, ventral striatum, hypothalamus, insula, amygdala and hippocampus. 16 healthy participants (8 males) were scanned on two separate test days, before and after eating a meal to satiation, or after not eating for 4 hours (satiated vs. pre-meal). fMRI BOLD signals to the sight and/or taste of the stimuli were recorded. Participants were given questionnaires to complete about their mood state and appetite before and after all scans.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Healthy volunteers

• Sufficiently fluent in English to understand the task and the instructions

Exclusion Criteria:

• Currently taking medication

• Past or current depression/dieting,

• Smokers

• Food allergies

• Diabetes

• Pregnancy

• BMI score outside the normal range

• Any contraindications to fMRI scanning (e.g. pacemakers, mechanical heart valve, hip replacement, metal implants)

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Appetite

Intervention

Other:
• Satiated / Pre-meal
All participants were scanned before and after not being fed (pre-meal), and before and after being given a satiating lunch (satiated).

Device:
• MRI

Locations

Country	Name	City	State
United Kingdom	University of Birmingham	Birmingham	West Midlands

Sponsors (2)

Lead Sponsor	Collaborator
University of Birmingham	University of Oxford

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Activation differences between satiated and pre-meal scan fMRI BOLD signal		6 months	No