Speeded Anomia Treatment in Chronic Post-stroke Aphasia

Aphasia Clinical Trial

Official title:

Testing the Effect of Speeded Anomia Therapy in Patients With Chronic Post-stroke Aphasia: a Cross-over Randomized Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05512884
• Other study ID #: 01/8/094
• Status: Recruiting
• Phase: N/A
• Start date: January 15, 2023
• Est. completion date: September 1, 2023

Study information

• Verified date: January 2023
• Source: University of Cambridge
• Contact: Eleni Zevgolatakou, MSc
• Phone: +447724386296
• Email: Elena.Zevgolatakou[@]mrc-cbu.cam.ac.uk
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).

Description:

The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: September 1, 2023
• Est. primary completion date: September 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Native English speakers
• Age 18 years or above
• Stroke (any type) greater than 12 months post onset
• No history of neurological disorders / psychiatric disorders
• Normal or corrected-to-normal hearing & vision
• Able to give informed consent
• Currently not receiving Speech & Language therapy
• Minimal repetition skills (>40% on an immediate word repetition test)
• Evidence of naming difficulties (<90% in Boston Naming Test - Goodglass et al., 1983)

Exclusion Criteria:

• Non-native English speakers
• Less than 18 years old
• Stroke less than 12 months post onset
• History of neurological disorders / psychiatric disorders
• Uncorrected hearing & vision
• Unable to give informed consent
• Currently receiving Speech & Language therapy
• Insufficient repetition skills (<40% on an immediate word repetition test)
• Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)

Related Conditions & MeSH terms

• Anomia
• Aphasia

Intervention

Behavioral:
• Speeded anomia therapy
The speeded anomia therapy was introduced as RISP (Repeated, Increasingly Speeded Production) by Conroy et al. (2018). Participants are asked to name the picture presented to them before an auditory stimulus ('beep' sound) at the end of item presentation. In each session the allotted response time is gradually reduced. After an incorrect response, participants are asked to repeat the word three times.

Locations

Country	Name	City	State
United Kingdom	MRC Cognition & Brain Sciences Unit	Cambridge

Sponsors (2)

Lead Sponsor	Collaborator
University of Cambridge	Cambridge University Hospitals NHS Foundation Trust

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Conroy P, Sotiropoulou Drosopoulou C, Humphreys GF, Halai AD, Lambon Ralph MA. Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. Brain. 2018 Jun 1;141(6):1815-1827. doi: 10.1093/brain/awy087. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Speeded anomia therapy effect in reaction time	Change in reaction time in single-item picture naming	Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Primary	Speeded anomia therapy effect in accuracy	Change in accuracy in single-item picture naming	Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Primary	Generalisation to connected speech	Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).	Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Secondary	Generalisation to story-telling connected speech	Change in narrative speech production. Participants will be asked to narrate the Cinderella story. A checklist with some of the most frequently used nouns (data obtained from AphasiaBank database) will be used.	Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)