Aphasia Clinical Trial
Official title:
Word-Retrieval for Aphasia: Facilitation of Generalization
Verified date | December 2014 |
Source | VA Office of Research and Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words.
Status | Completed |
Enrollment | 110 |
Est. completion date | April 2013 |
Est. primary completion date | February 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 21 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits - At least 6 months post-onset of single, left-hemisphere stroke - Minimum of high-school education - Visual and auditory acuity sufficient for experimental tasks - Nonverbal intelligence within normal limits Exclusion Criteria: - Diagnosed mental illness other than depression - Neurological condition other than that which resulted in aphasia - History of alcohol or substance abuse - Non-native English speaker - Premorbid history of speech/language disorder |
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | VA Salt Lake City Health Care System, Salt Lake City | Salt Lake City | Utah |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Wambaugh JL, Mauszycki S, Cameron R, Wright S, Nessler C. Semantic feature analysis: incorporating typicality treatment and mediating strategy training to promote generalization. Am J Speech Lang Pathol. 2013 May;22(2):S334-69. doi: 10.1044/1058-0360(2013 — View Citation
Wambaugh JL, Mauszycki S, Wright S. Semantic feature analysis: Application to confrontation naming of actions in aphasia. Aphasiology. 2013 Oct 28; 28(1):DOI:10.1080/02687038.2013.845739.
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Word Retrieval Accuracy | Accuracy of naming of pictured treated and untreated items was assessed in probes conducted separate from treatment. Probes were conducted repeatedly throughout the study, from baseline (prior to treatment) to follow-up (6 weeks following treatment). All naming responses were scored using a 0-10 scale reflecting promptness and presence of errors; scores of 8-10 received an "accuate" score and scores of 0-7 received an "inaccurate" score. A percentage accuracy score was calculated for each experimental set of items for every probe session. Baseline probe scores were compared to end of treatment and follow-up probe scores to obtain individual effect sizes for each experimental list of items for each participant (i.e., several effect sizes were calculated for each participant). All effect sizes were utlized to obtain an average effect size for each participant; these averages were then utlized to obtain a group average. | End of treatment and at 6 weeks post treatment | No |
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