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Aphasia, Primary Progressive clinical trials

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NCT ID: NCT05444244 Completed - Alzheimer Disease Clinical Trials

A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

Despite well-documented disparities in Alzheimer's disease and related dementia (AD) prevalence, incidence, treatment, and mortality, individuals from disadvantaged backgrounds (e.g. racial/ethnic minorities and socioeconomically disadvantaged persons) are under-represented in clinical research. Existing research recruitment approaches are rarely designed to accommodate the priorities, concerns, and constraints relevant to participants from diverse backgrounds. To address these gaps, the investigators developed a research recruitment and engagement model, the Participant Oriented Research Engagement Model that centers and prioritizes relational aspects of research engagement, research participant needs, and systematically address socioeconomic determinants (i.e. unmet needs) that may limit accessibility of research. The investigators propose to test the effectiveness of the Brain Health Community (BHC) Registry recruitment and engagement intervention, as compared to standard research recruitment strategies in modifying enrollment rates, participant satisfaction, and engagement. The investigators hypothesize that the BHC Registry will yield greater enrollment rates, higher satisfaction, and better ratings of relational engagement.

NCT ID: NCT05338710 Completed - Clinical trials for Frontotemporal Dementia

Support Via Technology: Living and Learning With Advancing FTD

STELLA-FTD
Start date: January 14, 2021
Phase: N/A
Study type: Interventional

Much effort over the last several decades has been devoted to developing and implementing psychoeducational interventions for family caregiving partners for those with Alzheimer's and relatedm dementias (ADRD). However, few interventions address the specific needs of care partners for those with frontotemporal degeneration (FTD). This study tests an intervention to support family caregivers for those with FTD.

NCT ID: NCT05019014 Completed - Alzheimer Disease Clinical Trials

Olfactory Deficits in Neurologic Disease

Start date: August 10, 2011
Phase:
Study type: Observational

The goal of this study is to examine olfactory function in preclinical subjects or individuals with neurological diseases such as Probable Alzheimer's Disease (PRAD), Frontotemporal Dementias (FTD), Dementia with Lewy Bodies (DLB), Traumatic Brain Injury (TBI), and Amyotrophic Lateral Sclerosis (ALS).

NCT ID: NCT04977245 Completed - Dementia Clinical Trials

Mindfulness-Based Stress Reduction in Dementia Caregivers

MBSR
Start date: August 12, 2021
Phase: N/A
Study type: Interventional

Aims: The study will contribute to our understanding of how the cultivation of caregiver mindfulness might improve their overall relational well-being (Primary Outcome), their psychological well-being (Secondary Outcome), and have an impact on dementia patients' lifestyles (Other Outcome). Overall, this study will investigate the idea that the fruits of mindfulness training can be leveraged by both the caregiver and the care-recipient, improving the quality of relationship by making their interactions more mutual, connected, empathic and positive. This study aims to additionally elucidate which facets of mindfulness account for caregiver's happiness and psychological well-being. Sample: In this study 40 dementia caregivers will be recruited to participate; 20 will be allocated to the clinical intervention group (i.e., adapted MBSR for caregivers) and 20 to the active control group. Data will be collected pre-post the start of intervention, and at a 3 month follow up. Future orientation: This study may contribute to evidence-based knowledge concerning the efficacy of mindfulness based interventions to support caregiver empowerment, via regaining relationship satisfaction and achieving greater equanimity in the face of stressors.

NCT ID: NCT04939818 Completed - Parkinson Disease Clinical Trials

Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders

RHAPSODY
Start date: June 14, 2021
Phase:
Study type: Observational [Patient Registry]

The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by the average length of speech elicitation for each speech task during the first week of self-assessment. Secondary objectives include (1) evaluating the reliability of speech tasks in the remote self-administered setting, as measured by the intra- and inter-subject variance; (2) accessing the adherence of speech tasks in this setting, as measured by the subject average fraction of days during the first week, where at least one task response is submitted; (3) evaluating the feasibility of using speech tasks in the setting of a telemedicine videoconference, as measured by the average length of speech elicited in each group; (4) evaluate whether a set of acoustic and linguistic patterns can detect each indication, compare to either a control group or all other indications, as measured by the area under the receiver operating characteristic curve (AUC), sensitivity, specificity and Cohen's kappa of the relevant binary classifier; (5) evaluating how the performance of such algorithms can be impacted by speaker and environment covariates, as measured by the Kendall rank correlation coefficient of the AUC of each classifier and each of age group, gender and speech-to-reverberation modulation energy ratio.

NCT ID: NCT04748263 Completed - Clinical trials for Alzheimer's Dementia

Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)

EYE-ToM
Start date: July 1, 2015
Phase:
Study type: Observational

It is commonly admitted that social cognition impairment, like deficit in facial emotion recognition or misinterpretation of others' intentions (Theory of Mind), are associated with social behavior disorders. This kind of disorders are observed in Fronto-Temporal Dementia (FTD), Alzheimer's Dementia (AD) and Parkinson's Disease (PD), with severe deficits in FTD and lighter deficits in AD and PD. One explanation might be that patients apply inappropriate visual exploration strategies to decode emotions and intentions of others. This study aims to test this hypothesis and further to analyse whether different patterns emerge from these pathologies.

NCT ID: NCT04726527 Completed - Alzheimer Disease Clinical Trials

Clinical Evaluation of Florbetapir in Primary Progressive Aphasia

PPA
Start date: March 15, 2012
Phase:
Study type: Observational

The purpose of this research is to better understand how dementia affects activity in different parts of the brain.

NCT ID: NCT04720001 Completed - Alzheimer Disease Clinical Trials

Florbetaben PET Imaging in PPA

Start date: August 23, 2018
Phase:
Study type: Observational

The purpose of this research is to better understand how dementia affects activity in different parts of the brain.

NCT ID: NCT04686266 Completed - Clinical trials for Caregiver Stress Syndrome

Improving Self-Care of Behavioral Variant Frontotemporal Dementia Caregivers

ViCCY
Start date: December 16, 2020
Phase: N/A
Study type: Interventional

The research study is being conducted to evaluate the efficacy of a virtual support intervention to reduce stress and poor self-care for caregivers of persons with behavioral variant Frontotemporal Degeneration (bvFTD) compared to receiving health information alone.

NCT ID: NCT04665622 Completed - Parkinson Disease Clinical Trials

Assessment of Empathetic Process by Scanpath Study of an Artwork

EYE-EMPATH
Start date: April 1, 2016
Phase: N/A
Study type: Interventional

Analysis of gaze patterns during social cognition tasks and standardised exploration of a specific artwork, between elderly subjects without cognitive disorders and subjects with neurodegenerative diseases such as Fronto-Temporal Dementia, Alzheimer's Dementia or Parkinson's Disease