Folic Acid Supplementation in Calcific Aortic Valve Disease

Status Not yet recruiting

Clinical Trial Summary

This is a prospective, randomized, comparative, clinical trial conducted by Wuhan Union Hospital that aims to evaluate the efficacy and safety of folic acid compared to placebo in patients with calcific aortic valve disease with mild aortic valve stenosis.

Clinical Trial Description

Folic acid is involved in important physiological activities in the body such as DNA synthesis, cell division and growth and development. Recent studies have shown that folic acid may also have a positive effect on cardiovascular system health. Aortic valve calcification is a cardiovascular disease whose incidence increases progressively with age. Early studies suggest that folic acid may slow the progression of aortic valve calcification by inhibiting cell calcification and promoting calcium deposition. Participants were randomized into two groups: one group was given oral folic acid treatment and the other group was given placebo control. Patients in both groups were observed for aortic valve calcification during the follow-up period, and changes in aortic valve thickness, degree of calcification, and flow were recorded by cardiac ultrasonography, while the incidence of cardiovascular events and adverse effects were assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05861648
Study type	Interventional
Source	Wuhan Union Hospital, China
Contact	Fei Li, MD
Phone	15972969897
Email	lifei_union@hust.edu.cn
Status	Not yet recruiting
Phase	Phase 2
Start date	July 1, 2023
Completion date	July 1, 2028

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