Aortic Valve Stenosis Clinical Trial
Official title:
Utilization of Cardiac Magnetic Resonance Imaging to Predict Clinical Outcomes of Patients With Severe Aortic Stenosis
Background:
- Aortic valve stenosis is a disease that makes a major heart valve get smaller. This reduces
heart function and causes death. Severe aortic stenosis (AS) can be treated in a couple of
ways, including replacing a heart valve.
Objectives:
Researchers want to study fibrosis in the heart. A sub-study will test whether heart function
and blood supply improve after a valve replacement.
Eligibility:
- Adults at least 18 years old with aortic stenosis.
Design:
- Participants will visit a clinic for 1 day for magnetic resonance imaging (MRI) of their
heart. This uses magnets, radio waves, and computers to produce detailed pictures of the
heart.
- After this visit, participants will have their aortic valve procedure at the the
Washington Hospital Center. A hospital team will contact participants for 1 year by
phone or email. This follow-up will consist of 15 minutes of questions about the
participant s health status.
- Some participants will join a sub-study.
- They will be given an additional medication to evaluate the blood supply of the heart.
- They will visit a clinic for 1 day for an MRI of their heart, as part of the main study,
prior to the aortic valve replacement.
- After they have their valve replaced at the hospital, they will return to the clinic for
another MRI.
- They will have the same follow-up as in the main study.
Aortic valve stenosis is a disease that causes narrowing of a major heart valve, and that reduces heart function and causes death. The purpose of this protocol is to use magnetic resonance imaging of the heart to identify which patients would benefit from replacement of the diseased valve. ;
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