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Phenotyping Heterogeneity and Regionality of the Aorta — PHaRAo  

Aortic Stenosis Clinical Trial

Official title:
Phenotyping Heterogeneity and Regionality of the Aorta

Clinical Trial Summary

The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05603520
Study type Observational
Source Heinrich-Heine University, Duesseldorf
Contact Christine Quast, MD
Phone +492118118800
Email Christine.Quast@med.uni-duesseldorf.de
Status Recruiting
Phase
Start date October 18, 2020
Completion date June 30, 2027
View Details
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