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Mechanism of Decompensation Evaluation - Aortic Stenosis — MODE-AS  

Aortic Stenosis Clinical Trial

Official title:
Mechanism of Left Ventricular Decompensation Evaluation - Aortic Stenosis

Clinical Trial Summary

Aortic stenosis is the most common heart valve disease requiring intervention in high income countries. It is characterised by progressive valvular thickening, and restriction as well is hypertrophy and fibrosis of the left ventricle in response to pressure overload. The pathological processes in the left ventricle that ultimately result in heart failure and death are incompletely understood. Further elucidation of these processes and how they correlate with novel blood biomarkers may help us design new treatments and optimise the timing of surgical intervention. In brief, recruited patients with severe aortic stenosis and scheduled to undergo valve replacement surgery will be invited for some simple tests (blood sampling, ECG, echocardiogram). A septal myocardial biopsy will be taken at the time of surgery and the disease valve retained. These will be examined histologically and pathological changes compared with results obtained from ECG, echocardiogram and blood tests.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03332745
Study type Observational
Source University of Edinburgh
Contact
Status Completed
Phase
Start date September 3, 2018
Completion date July 31, 2023
View Details
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