Aortic Stenosis Clinical Trial
Official title:
Comparison of Blood and Crystalloid Cardioplegia on Patients Operated With Significant Aortic Stenosis. A Prospective Randomized Study.
The investigators decided to make a study with a cohort of patients as homogenous as possible with a cross clamp time around 70 min. Adult patients with a severe aortic stenoses without any other significant heart disease was included in our prospective randomised study. This group of patients was chosen for two reasons. First, these patients have left ventricular hypertrophy making the myocardium vulnerable to ischemia, secondly the investigators wanted to avoid the possible confounding effect of ischemia found in patients with variable degrees of coronary artery disease. Therefore, patients with additional significant coronary artery disease (≥ 50% stenoses) were excluded from the study.
Objective: Myocardial protection during a cardiac arrest is mostly managed with cardioplegia.
To day we normally used a blood or crystalloid based solutions. It has been published a lot
of papers comparing the too groups with different results. To our knowledge no prospective,
randomized study has compared modified St Thomas based Blood and Crystalloid cardioplegia on
the acknowledged markers (CK-MB, troponin-T) of myocardial damage during aortic valve
replacement on patients without additional significant coronary artery disease.
Methods: 100 patients with aorta stenoses undergoing aortic valve replacement without
significant coronary artery stenoses or other significant concomitant heart valve disease
were included in the study. They were given antegrade cold blood or cold crystalloid
cardioplegia delivered through the coronary Ostia every 20 min throughout the period of
aortic cross-clamp. CK-MB and troponin-T were compared between the two groups.
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